Esophagitis in a High H. pylori Prevalence Area: Severe Disease Is Rare but Concomitant Peptic Ulcer Is Frequent

BACKGROUND Few data are available on the prevalence of erosive and severe esophagitis in Western countries. OBJECTIVE To retrospectively determine the prevalence and the factors predicting erosive esophagitis and severe esophagitis in a large series of endoscopies in Spain. DESIGN Retrospective observational study. A multivariate analysis was performed to determine variables predicting severe esophagitis. SETTING Databases of 29 Spanish endoscopy units. PATIENTS Patients submitted to a diagnostic endoscopy during the year 2005. INTERVENTIONS Retrospective review of the databases. MAIN OUTCOME MEASUREMENTS Esophagitis severity (graded according to the Los Angeles classification) and associated endoscopic findings. RESULTS Esophagitis was observed in 8.7% of the 93,699 endoscopies reviewed. Severe esophagitis (LA grade C or D) accounted for 22.5% of cases of the disease and was found in 1.9% of all endoscopies. Incidences of esophagitis and those of severe esophagitis were 86.2 and 18.7 cases per 100,000 inhabitants per year respectively. Male sex (OR 1.89) and advanced age (OR 4.2 for patients in the fourth age quartile) were the only variables associated with severe esophagitis. Associated peptic ulcer was present in 8.8% of cases. LIMITATIONS Retrospective study, no data on individual proton pump inhibitors use. CONCLUSIONS Severe esophagitis is an infrequent finding in Spain. It occurs predominantly in males and in older individuals. Peptic ulcer disease is frequently associated with erosive esophagitis.